Application

Research Sub CategoryIntegrins

Research CategoryCell Structure

Components

beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20)- 1 tube, 20 µg.alpha1 Mouse Monoclonal Antibody (Part No. MAB1973Z-20) - 1 tube, 20 µg.alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 µg.alpha3 Mouse Monoclonal Antibody (Part No. MAB1952Z-20) - 1 tube, 20 µg.alpha4 Mouse Monoclonal Antibody (Part No. MAB16983Z-20) - 1 tube, 20 µg.alpha5 Mouse Monoclonal Antibody (Part No. MAB 1956Z-20) - 1 tube, 20 µg.alpha6 Rat Monoclonal Antibody (Part No. MAB1378-20)- 1 tube, 20 µg.alphaV Mouse Monoclonal Antibody (Part No. MAB1953Z-20)- 1 tube, 20 µg.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The beta1 Integrin Partners Investigator Kit is designed for research focused on the human beta1 integrin subunit and those integrin subunits known to pair with beta1, including alpha1, alpha2, alpha3, alpha4, alpha5, alpha6 and alphaV.

Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

Chemicon offers the b1 Integrin Partners Investigator Kit for initial studies of b1 subunit interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.

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Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

With 20 µg each of monoclonals to alpha1, alpha2, alpha3, alpha4, alpha5, alpha6, alphaV, and beta1. Chemicon′s beta1 Integrin Kit (ECM445) provides a cost-effective means to study the beta1 integrin and its associated alpha subunits.